李志强  博士  副教授  硕士生导师

联合培养单位：河南师范大学

地址：睢阳校区生物与食品学院

教育经历

2009.08-2015.07，石河子大学，博士（导师：陈创夫教授）

2005.09-2009.07，河北科技师范学院，学士（导师：李佩国教授）

工作经历

2015年7月至今 商丘师范学院生物与食品学院，讲师、副教授

2022年3月任商丘师范学院生命健康产业学院技术中心主任

主讲课程

家畜解剖及组织胚胎学，人体组织解剖学，动物病理学

研究方向

动物传染病致病机理及免疫防治

主持科研项目

[1]  布鲁氏菌转录因子GntR调控细胞凋亡的分子机制研究（编号31602080）, 国家自然科学基金，21万元，2016.01-2018.12，已结题

[2]  基于布鲁氏菌密度感应系统转录激活因子VjbR和BlxR新型亚单位疫苗株的构建及免疫效果的评价（编号212102310746），河南省重点研发与推广专项（科技攻关）项目，2021.01-2022.12，已结题

[3]  新型布鲁氏菌疫苗株的构建与毒力评价（编号172102310335），河南省重点研发与推广专项（科技攻关）项目，2017.01-2018.12，已结题

[4]  布鲁氏菌OMP25家族新型重组蛋白疫苗株的构建及免疫效果的评价（编号21A230015），河南省高等学校重点科研项目，3万元，2021.01-2022.12，已结题

[5]  布鲁氏菌NodVW基因标记疫苗株的构建、免疫保护性分析及鉴别诊断研究（编号16A230013），河南省高等学校重点科研项目，3万元，2016.01-2017.12，已结题

代表性研究成果

1. 论著

[1] Zhiqiang Li, Shuli Wang, Shujuan Wei, Guangli Yang, Chunmei Zhang, Li Xi, Jinliang Zhang, Yanyan Cui, Junfang Hao, Huan Zhang, Hui Zhang*. Immunization with a combination of recombinant Brucella abortus proteins induces T helper immune response and confers protection against wild-type challenge in BALB/c mice. Microbial Biotechnology, 2022, 15(6): 1811-1823.

[2] Chuanxin Shi^#, Shuli Wang^#, Jincheng Han, Li Xi, Min Li, Zhiqiang Li*, Hui Zhang*. Functional insights into Bucella transcriptional regulator ArsR. Microbial Pathogenesis, 2022, 168: 105557.

[3] Shuli Wang^#, Zhiqiang Li^#, Jinliang Zhang, Li Xi, Yanyan Cui, Wehihua Zhang, Junbo Zhang, Hui Zhang. A safe non-toxic Brucella abortus ghosts induce immune responses and confer protection in BALB/c mice. Molecular Immunology, 2020, 124: 117-124.

[4] Xingmei Deng^#, Min Li^#, Liangbo Liu, Jing Zhang, Yu Zhang, Jia Guo, Tianyi Zhao, Shuzhu Cao, Zhiqiang Li*, Hui Zhang*. Functional analysis of Bucella reveals transcriptional regulation of MarR. Microbial Pathogenesis, 2020, 144: 104201.

[5] Zhiqiang Li^#, Min Li^#, Hui Zhang, Shuli Wang, Li Xi, Xiaogen Zhang, Jihai Yi, Huan Zhang*. ChIP-seq analysis of Brucella reveals transcriptional regulator of GntR. Journal of Basic Microbiology, 2020, 60(2): 149-157.

[6] Zhiqiang Li^#, Shuli Wang^#, Hui Zhang*, Li Xi, Jinliang Zhang, Xiaogen Zhang, Qingfeng Zhou, Jihai Yi, Min Li, Weihua Zhang, Junbo Zhang. Development and evaluation of in murine model, of an improved live-vaccine candidate against brucellosis from to Brucella melitensis vjbR deletion mutant. Microbial Pathogenesis, 2018, 124: 250-257.

[7] Zhiqiang Li, Hui Zhang*, Jinliang Zhang, Li Xi, Guangli Yang, Shuli Wang, Qingfeng Zhou, Xiaogen Zhang, Junbo Zhang. Brucella abortus phosphoglyceromutase and dihydrodipicolinate reductase induce Th1 and Th2-related immune responses. World Journal of Microbiology and Biotechnology, 2018, 34: 22.

[8] Zhiqiang Li, Jinliang Zhang, Li Xi, Guangli Yang, Shuli Wang, Xiaogen Zhang, Junbo Zhang, Hui Zhang*. Deletion of the transcriptional regulator GntR down regulated the expression of genes related to virulence and conferred protection against wild-type Brucella challenge in BALB/c mice. Molecular Immunology, 2017, 92: 99-105.

[9] Zhiqiang Li^#, Shuli Wang^#, Hui Zhang*, Li Xi, Jinliang Zhang, Xiaogen Zhang, Jincheng Han, Junbo Zhang. Immunization with recombinant GntR plasmid confers protection against Brucella challenge in BALB/c mice. Microbial Pathogenesis, 2017, 111: 357-361.

[10] Zhiqiang Li^#, Shuli Wang^#, Hui Zhang*, Jinliang Zhang, Li Xi, Junbo Zhang, Chuangfu Chen. Transcriptional regulator GntR of Brucella abortus regulates cytotoxicity, induces the secretion of inflammatory cytokines and affects expression of the type IV secretion system and quorum sensing system in macrophages. World Journal of Microbiology and Biotechnology, 2017, 33: 60.

[11] Zhiqiang Li^#, Shuli Wang^#, Jinliang Zhang, Guangli Yang, Baodong Yuan, Jie Huang, Jincheng Han, Li Xi, Yanren Xiao, Chuangfu Chen, Hui Zhang*. Brucella abortus 2308ΔNodVΔNodW double-mutant is highly attenuated and confers protection against wild-type challenge in BALB/c mice. Microbial Pathogenesis, 2017, 106: 30-39.

2. 专利

[1]  李志强，王书利，席丽，张春梅，施传信，张辽，一种动物传染病隔离用保温箱，中国实用新型专利，专利号：ZL201820950062.2.

[2]  李志强，王书利，席丽，张进良，崔艳艳，施传信，一种兽医专用治疗保持架，中国实用新型专利，专利号：ZL201920982229.8.

[3]  李志强，王书利，席丽，张进良，崔艳艳，施传信，一种动物灌药专用连续灌药装置，中国实用新型专利，专利号：ZL201920982228.3.

3. 学术奖励

[1]  李志强，王书利，李庆东，新型布鲁氏菌疫苗株的构建与毒力评价，商丘市科技进步奖二等奖，2022